Radical cystectomy for bladder cancer: oncologic outcome in 271 Chinese patients
نویسندگان
چکیده
Few large scale studies have reported the oncologic outcome of radical cystectomy for treating bladder cancer in China; hence, we lack long-term prognostic information. The aim of the current study was to determine the survival rate and prognostic factors of patients who underwent radical cystectomy for bladder cancer in a Chinese medical center. We retrospectively analyzed clinicopathologic data from 271 bladder cancer patients who underwent radical cystectomy between 2000 and 2011. Univariate and multivariate analyses were conducted to identify independent prognostic predictors for this cohort. Median follow-up was 31.7 months (range, 0.2-139.1 months). Thirty-day mortality was (1.4%). The 5-year recurrence-free survival, cancer-specific survival (CSS), and overall survival rates were 61.6%, 72.9%, and 68.0%, respectively. The 5-year CSS rates of patients with T1-T4 disease were 90.7%, 85.0%, 51.0%, and 18.0%, respectively. Patients with organ-confined disease had a higher 5-year CSS rate than those with extravesical disease (81.4% vs. 34.9%, P < 0.001). For the 38 patients (14%) with lymph node involvement, the 5-year CSS rate was 27.7%-significantly lower than that of patients without lymph node metastasis (P < 0.001). The 5-year CSS rate was much higher in patients with low grade tumor than in those with high grade tumor (98.1% vs. 68.1%, P < 0.001). Multivariate Cox regression showed that patient age (hazard ratio, 2.045; P = 0.013) and T category (hazard ratio, 2.213; P < 0.001) were independent predictors for CSS. These results suggest that radical cystectomy is a safe and effective method for treating bladder cancer in Chinese patients. Old age and high T category were associated with poor prognosis in bladder cancer patients who underwent radical cystectomy.
منابع مشابه
Indications and Oncologic Outcome of Radical Cystectomy for Urothelial Bladder Cancerâ€
Context: Radical cystectomy (RC) offers the best opportunity for ultimate cure of high-grade and high-risk invasive bladder cancer (BCa). Objective: To review the available literature on indications for and oncologic outcomes of RC for urothelial carcinoma of the bladder. Evidence acquisition: A database search of the US National Library of Medicine (PubMed) was performed for relevant medical a...
متن کاملA preliminary oncologic outcome and postoperative complications in patients undergoing robot-assisted radical cystectomy: Initial experience
PURPOSE Robot-assisted radical cystectomy (RARC) was originally intended to replace open radical cystectomy (ORC) as a minimally invasive surgery for patients with invasive bladder cancer. The purpose of this study was to evaluate the advantages of robotic surgery, comparing perioperative and oncologic outcomes between RARC and ORC. MATERIALS AND METHODS Between June 2012 and August 2016, 49 ...
متن کاملAB007. Bladder-sparing treatments for muscle-invasive bladder cancer
Radical cystectomy (RC) with pelvic lymph node dissection remains the gold-standard treatment for muscleinvasive bladder cancer (MIBC). Growing evidence suggests that bladder-sparing treatments may lead to acceptable oncologic outcomes in carefully selected patients and can offer improved quality of life through preservation of a functioning bladder. We summarize our clinical experience of blad...
متن کاملPreoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer
OBJECTIVE To evaluate the impact of preoperative chronic kidney disease (CKD) on oncologic outcomes in muscle-invasive bladder cancer patients who underwent radical cystectomy. METHODS A total of 581 patients who underwent radical cystectomy at four medical centers between January 1995 and February 2017 were examined retrospectively. We investigated oncologic outcomes, including progression-f...
متن کاملMicroscopic Study of Histological Changes the Use of Ileal Mucosa as a Bladder (Radical Cystectomy - Case Report)
Cancer can significantly have ruining effects on very high of human beings, social, and economic condition. Bladder cancer has been reported as one of the most common cancers and the incidence rates of this cancer is increasing across the world. Cystectomy is a surgery to remove the urinary bladder. In the present study a part of the ileum is used instead of bladder. This study deals with mucos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 33 شماره
صفحات -
تاریخ انتشار 2014